Monoclonal Antibody Companies Command Premiums

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Monoclonal Antibody Companies Command Premiums

Monoclonal antibodies, which have been approved for immunological, anti-infective, ophthalmic, cancer and other categories, represent one of the most successful therapeutic drug classes.  Ten monoclonal antibodies have been approved for cancer therapy alone, including three blockbuster products sold by the Roche Group (RHHBY) – Avastin® , Rituxan® , and Herceptin® that collectively represented...
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Five Key Factors Weighing on Dendreon

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Five Key Factors Weighing on Dendreon

Shares of Dendreon Corporation (DNDN) have declined significantly from an all-time high of $57.67 in late April 2010 when the company received U.S. Food and Drug Administration approval for Provenge® , the first active immunotherapy approved for the treatment of cancer in the U.S.  Today, shares of Dendreon traded as low as $28.01,...
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Innovative New Medicines are Key to Economic Growth

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Innovative New Medicines are Key to Economic Growth

The life sciences industry plays a critical role in the United States economy.  Innovative new medicines developed by life sciences companies provide better patient outcomes, improved quality of care, increased life expectancy, and lead to economic gains. Currently, the strengths [e.g. innovation, quality of...
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Bridging the Gap – Translating NIH Funding in a Post-Stimulus Economy

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Bridging the Gap – Translating NIH Funding in a Post-Stimulus Economy

On February 17, 2009, President Obama announced as part of the 2009 stimulus bill, an increase of approximately $10B dollars to the budget for the National Institute of Health (NIH). This is a much needed increase in funding as government sponsored biomedical research has remained relatively flat over the past several years (Figure 1)....
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Innovative Science Briefs

New generation of medicines targeting G-protein coupled receptors (GPCRs)

New generation of medicines targeting G-protein coupled receptors (GPCRs)

Heterotrimeric G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors (1) and play a critical role in transmitting signals from outside to inside a cell.   GPCRs role in cell physiology and pathophysiology is well documented as nearly all physiological functions are dependent on GCPR signaling (1,2). The activation of a GPCR...