February 5, 2012

Ipilimumab Approval Highlights Immunotherapy Renaissance

mab_slide

On March 25, 2011, Yervoy® [ipilimumab] by Bristol-Myers Squibb became the eleventh mAb approved by the FDA for the treatment of cancer.

FDA Approved Monoclonal Antibodies (mAbs) for Cancer Therapy

Graph of FDA Approved Monoclonal Antibodies (mAbs) for Cancer Therapy

The following image may be reproduced without modification using the attribution “Graph source – MD Becker Partners (www.mdbpartners.com).”  Click on the image to enlarge.

Monoclonal Antibody Companies Command Premiums

Monoclonal antibody image from MD Becker Partners

Monoclonal antibodies, which have been approved for immunological, anti-infective, ophthalmic, cancer and other categories, represent one of the most successful therapeutic drug classes.  Ten monoclonal antibodies have been approved for cancer therapy alone, including three blockbuster products sold by the Roche Group (RHHBY) – Avastin® [bevacizumab], Rituxan® [rituximab], and Herceptin® [trastuzumab] that collectively represented nearly [...]

Cancer Vaccine Therapies: Failures and Future Opportunities

FIGURE 1: FDA APPROVAL OF CANCER MABS FROM 1997-2010

(Note: the following text is an Executive Summary from our new 150-page report titled “Cancer Vaccine Therapies: Failures and Future Opportunities”) Since the early 1990s, cancer immunotherapy has provided hope to patients, physicians, and investors as a new treatment modality with limited side effects and superior efficacy.  Cancer immunotherapy broadly includes passive immunization, active immunization, [...]